High-throughput post-genomic studies are now routinely and promisingly investigated in biological and biomedical research. The main statistical approach to select genes differentially expressed between two groups is to apply a t-test. which is subject of criticism in the literature. Numerous alternatives have been developed based on different and innovative variance modeling strategies. https://www.aitsglobal.com/product-category/%d7%99%d7%9c%d7%93%d7%99%d7%9d/