Anal fissure is an ischemic ulcer that occurs in anoderm and it has no obvious etiology and pathophysiology in current medicine. Anal fissure has a profound history in Persian and Persian medicine and wallflower (Erysimum cheiri (L. ) Crantz) has been a common medication in this case. https://www.marcelovicente.com/product-category/wave-flexible-spray-gel/