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Stabilizing Prefusion SARS-CoV-2 Spike by Destabilizing the Postfusion Conformation

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Background/Objectives: As with many viral fusion proteins. the native conformation of SARS-CoV-2 Spike is metastable. Most COVID-19 vaccines utilize a stabilized Spike (Spike-2P) containing two proline substitutions. and subsequently. https://parisnaturalfoodes.shop/product-category/buckwheat-groats/
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