Summary: CHK1 inhibitors exhibit dose-limiting toxicity despite potent tumor cytotoxicity in clinical trials. Here. we reveal that low-dose prexasertib induces mtDNA damage by impairing repair machinery. triggering cytosolic mtDNA release via VDAC1 to activate STING-mediated innate immunity. https://missouriquiltcoes.shop/product-category/apron-patterns/