PIKfyve is an endosomal lipid kinase that synthesizes phosphatidylinositol 3. 5-biphosphate from phosphatidylinositol 3-phsphate. Inhibition of PIKfyve activity leads to lysosomal enlargement and cytoplasmic vacuolation. attributed to impaired lysosomal fission processes and homeostasis. https://www.itsmajorlook.com/