Due to the immunosuppressive microenvironment as well as the lack of medicine that targets the driver gene alterations. the prognosis of patients with pancreatic ductal adenocarcinoma(PDAC)is worse than that of other malignant tumors. At present. chemotherapy is still the main stay of treatment for most patients with advanced PDAC. https://npdihebvubpxiu.celticwiki.com/1456197/hidden_markov_model_based_p2p_flow_identification_technique